Highlight your ingredients’ power to boost cellular energy metabolism, fitness, and longevity.
Mitologics provides expert, customized testing solutions to scientifically support your nutraceutical and cosmetic claims with proven effects on mitochondrial activity.
Mitochondrial dysfunction plays a significant role in the biological ageing process. It is characterized by several signatures: impaired OxPHOS activity, excessive oxidative stress, decline in mitochondrial quality control and metabolic enzymes activities, and changes in mitochondrial morphology, dynamics, and biogenesis.

Anti-ageing solutions thus include strategies to stimulate mitochondrial activity or protect mitochondria from oxidative stress:
– To evaluate the direct benefits of ingredients on mitochondrial function and cellular fitness, Mitologics proposes assays on primary cells, including keratinocytes and dermal fibroblasts. These are derived from young, middle-aged, and elderly donors, using both early and late cell passages (replicative senescence).
– To assess the protective effects of ingredients against oxidative stress, Mitologics offers assays on keratinocytes and dermal fibroblasts exposed to oxidative stress, hypoxia, with or without nutrient deprivation.
Modulating mitochondrial activity through the uncoupling effect, and activation of mitochondrial biogenesis can also have a beneficial impact in adipose tissue, reducing the fat mass by oxidising fatty acids. This change in metabolism leads to trans-differentiation of white adipocytes to a brown-like phenotype, as part of effective weight-loss strategies to induce a slimming effect:
– To assess the slimming potential of ingredients, Mitologics offers assays on human white adipocytes to investigate the induction of a brown-like adipocyte phenotype.
At Mitologics, all the tests for cosmetic & nutraceutical industries purposes rely on the MitoXpert® platform:
With MitoXpert®, you can assess the efficacy of ingredients on key mitochondrial functions linked to:
- energetic metabolism
- mitochondrial membrane integrity
- dynamics of the mitochondrial network
- oxidative stress
- cell death
As an alternative to animal testing, our assays performed on cultured human cells or isolated mitochondria from human cell lines, allow stakeholders in the cosmetics industry to gain an understanding of the mechanisms underlying the protective properties of new ingredients.