Scientific advisory board
Mitologics is sponsor of the 3
World Congress on Targeting Mitochondria and will present its screening assay on isolated liver mitochondria (MiToxView platform) predictive for hepatotoxicity risks in human.
(8/9 October 2012 - Berlin - Germany)
Aftins Increase Amyloid-β42, Lower Amyloid-β38, and Do Not Alter Amyloid-β40 Extracellular Production in vitro: Toward a Chemical Model of Alzheimer's Disease?
2013 - J Alzheimers Dis.
Hôpital Robert Debré
48, Boulevard Sérurier
Download our PDF brochure
Mitologics SAS - 2009
Webmaster: Jérôme FLATOT
Isolation of mitochondria
As quality of mitochondria is critical to perform such screening assays, we used several parameters to evaluate their integrity and functionality.
Highly purified mitochondria
Tumor cell line
Toxicity and efficacy assays on mitochondria from different origins
Mitologics is currently setting up new protocols to purify mitochondria from other healthy and pathological sources.
Protection assays of mitochondria from healthy organs
Mitologics proposes protection assays on liver and heart mitochondria against:
calcium-induced damages (Permeability Transition Pore, PTP)
potassium-induced damages (MitoK(ATP) channels)
apoptotic stress (Bax/Bak pore)
Mitologics is using Standard Operating Procedures (SOP) for the preparation of healthy and tumor mitochondria.
Mitologics can propose:
standard studies on their mitochondrial types
specific studies using mitochondria from other sources. For each new type a feasibility study will be run first.